2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140013
    Fmoc-NH-PEG1-C2-acid 1654740-73-4 99.83%
    Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG1-C2-acid
  • HY-W008879
    Mal-amido-PEG6-NHS ester 1137109-21-7 98.76%
    Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG6-NHS ester
  • HY-133063
    Fmoc-NH-PEG8-CH2COOH 868594-52-9 99.41%
    Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG8-CH2COOH
  • HY-W038771
    THP-PEG1-alcohol 2162-31-4 99.53%
    THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG1-alcohol
  • HY-W052006
    m-PEG7-thiol 651042-82-9 99.92%
    m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-thiol
  • HY-141329
    m-PEG6-thiol 441771-60-4
    m-PEG6-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG6-thiol
  • HY-126976
    Propargyl-PEG5-amine 1589522-46-2 98.86%
    Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-amine
  • HY-140977
    Mal-amido-PEG12-NHS ester 2101722-60-3 98.52%
    Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG12-NHS ester
  • HY-W250928B
    Biotin-PEG-azide (MW 1000) 956494-20-5
    Biotin-PEG-azide (MW 1000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Biotin-PEG-azide (MW 1000)
  • HY-W046348
    22-(tert-Butoxy)-22-oxodocosanoic acid 1642333-05-8 99.07%
    22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
    22-(tert-Butoxy)-22-oxodocosanoic acid
  • HY-140413
    Boc-aminoxy-PEG4-acid 2062663-68-5 98.0%
    Boc-aminoxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-aminoxy-PEG4-acid
  • HY-138430
    Mal-PEG2-NHS 329364-72-9
    Mal-PEG2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-NHS
  • HY-W002886
    N-Boc-cis-4-hydroxy-L-proline 87691-27-8 ≥98.0%
    N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
    N-Boc-cis-4-hydroxy-L-proline
  • HY-140073
    endo-BCN-PEG4-PFP ester 2904607-26-5
    endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG4-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG4-PFP ester
  • HY-170528
    DBCO-PEG3-NHS 2249926-63-2 98.0%
    DBCO-PEG3-NHS is a biochemical assay reagent, that can be used to chemically modify proteins and antibodies with an alkynyl (DBCO) or N-hydroxysuccinimide (NHS) ester group. DBCO-PEG3-NHS can be used as a linker in PROTAC synthesis or for drug delivery and the development of biosensors and diagnostic reagents.
    DBCO-PEG3-NHS
  • HY-W012862
    Methyl-PEG2-alcohol 111-77-3 99.97%
    Methyl-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl-PEG2-alcohol
  • HY-133271
    m-PEG4-SH 52190-55-3 99.84%
    m-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-SH
  • HY-140228
    m-PEG24-NH2 2151823-08-2 99.96%
    m-PEG24-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-NH2
  • HY-35261A
    Mal-PEG2-NH2 TFA 660843-23-2 99.37%
    Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-NH2 TFA
  • HY-W040245
    Fmoc-amino-PEG5-acid 882847-32-7 99.51%
    Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-amino-PEG5-acid
PROTAC Linkers Isoform Comparison

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